Keystone Symposia is kindly inviting you to participate in a symposia on “Cell Death Signaling in Cancer and the Immune System” to be held on October 28 – November 2, 2014 in Guarujá, São Paulo, Brazil at the Casa Grande Hotel. The event is organised in collaboration with the São Paulo Research Foundation (FAPESP) and the National Council for Scientific and Technological Development (CNPq) – Brazil.
Cellular decisions to live or die are fundamental to development and adult homeostasis, playing roles in a wide variety of physiological and pathological processes. These include cancer, degenerative disease, innate and adaptive immunity, ischemia-reperfusion injury, and infectious disease.
Over the past decades, the fundamental molecular mechanisms underlying one form of cell death, apoptosis, have been largely defined. Other forms of cell death, such as programmed necrosis or autophagic cell death, are not as well understood.
In this meeting, the pathways that impact on a cell’s decision to live or die will be presented in the context of physiology and disease, and ways to influence that decision therapeutically will be explored. The consequence of cell death for the body is also of great interest, as the clearance of dying cells impacts on other physiological processes.
The successful elucidation of the molecular pathways controlling and mediating apoptosis have come to fruition as agents for cancer and other therapies are entering the clinic. Similar promise exists for other forms of cell death as our knowledge of these advances. In addition, we are beginning to understand how processes relating to cell death and survival play roles in other biological processes, such as the secretion of cytokines and the response to infection.
This meeting will bring together researchers in the fields of cell death and survival from around the world. As the study of cell death moves beyond the central mechanisms of apoptosis to wider issues of regulation and other forms of cell death, this vibrant area of research widens its influence and importance for human health and disease.
Topics and Speakers
Wednesday, October 29, 2014
- Keynote Address – Vishva M. Dixit, Genentech, Inc., USA
- “Cell Death Signaling I” – Guy S. Salvesen, Sanford-Burnham Medical Research Institute, USA – Beth Levine, University of Texas Southwestern Medical Center, USA – Mohanish Deshmukh, University of North Carolina at Chapel Hill, USA
- Workshop: “Cancer“
- “Cell Death Signaling II” – Douglas R. Green, St. Jude Children’s Research Hospital, USA – Peter Vandenabeele, VIB, Ghent University, Belgium – Francis Ka-Ming Chan, University of Massachusetts Medical School, USA
Thursday, October 30, 2014
- “Cell Death and Cancer I” – Andreas E. Strasser, Walter and Eliza Hall Institute of Medical Research, Australia – David W. Andrews, University of Toronto, Canada – Gerry Melino, University of Rome ‘Tor Vergata’, Italy – Ruslan M. Medzhitov, HHMI/Yale University School of Medicine, USA
- Workshop: “Host Defense“
- “Cell Death and Cancer II” – Gerard I. Evan, University of Cambridge, UK – Karen H. Vousden, Beatson Institute for Cancer Research, UK – Anthony G. Letai, Dana-Farber Cancer Institute, USA
Friday, October 31, 2014
- “Cell Death and Host Defense I” – Petr Broz, Biozentrum, University of Basel, Switzerland – Thirumala-Devi Kanneganti, St. Jude Children’s Research Hospital, USA – Karina R. Bortoluci, Federal University of São Paulo, Brazil
- “Cell Death and Host Defense II” – Akiko Iwasaki, Yale University School of Medicine, USA – Gustavo P. Amarante-Mendes, Universidade de São Paulo, Brazil – Seamus J. Martin, Trinity College Dublin, Ireland
Saturday, November 1, 2014
- “Consequences of Cell Death” – Shigekazu Nagata, Kyoto University, Japan – Kim Newton, Genentech, USA – Will Wood, University of Bristol, UK – Eric H. Baehrecke, University of Massachusetts Medical School, USA
- “Cell Death Therapies” – David Ching Huang, Walter and Eliza Hall Institute of Medical Research, Australia