Keystone Symposia: Cell Death Signaling in Cancer and the Immune System 2014 Sao Paulo

  • Conference Call
  • Key­stone Sym­posia is kindly invit­ing you to par­tic­i­pate in a sym­posia on “Cell Death Sig­nal­ing in Can­cer and the Immune Sys­tem” to be held on Octo­ber 28 – Novem­ber 2, 2014 in Guarujá, São Paulo, Brazil at the Casa Grande Hotel. The event is organ­ised in col­lab­o­ra­tion with the São Paulo Research Foun­da­tion (FAPESP) and the National Coun­cil for Sci­en­tific and Tech­no­log­i­cal Devel­op­ment (CNPq) – Brazil.

    Meet­ing Summary


    Cel­lu­lar deci­sions to live or die are fun­da­men­tal to devel­op­ment and adult home­osta­sis, play­ing roles in a wide vari­ety of phys­i­o­log­i­cal and patho­log­i­cal processes. These include can­cer, degen­er­a­tive dis­ease, innate and adap­tive immu­nity, ischemia-​reperfusion injury, and infec­tious disease.

    Over the past decades, the fun­da­men­tal mol­e­c­u­lar mech­a­nisms under­ly­ing one form of cell death, apop­to­sis, have been largely defined. Other forms of cell death, such as pro­grammed necro­sis or autophagic cell death, are not as well understood.

    In this meet­ing, the path­ways that impact on a cell’s deci­sion to live or die will be pre­sented in the con­text of phys­i­ol­ogy and dis­ease, and ways to influ­ence that deci­sion ther­a­peu­ti­cally will be explored. The con­se­quence of cell death for the body is also of great inter­est, as the clear­ance of dying cells impacts on other phys­i­o­log­i­cal processes.


    The suc­cess­ful elu­ci­da­tion of the mol­e­c­u­lar path­ways con­trol­ling and medi­at­ing apop­to­sis have come to fruition as agents for can­cer and other ther­a­pies are enter­ing the clinic. Sim­i­lar promise exists for other forms of cell death as our knowl­edge of these advances. In addi­tion, we are begin­ning to under­stand how processes relat­ing to cell death and sur­vival play roles in other bio­log­i­cal processes, such as the secre­tion of cytokines and the response to infection.

    This meet­ing will bring together researchers in the fields of cell death and sur­vival from around the world. As the study of cell death moves beyond the cen­tral mech­a­nisms of apop­to­sis to wider issues of reg­u­la­tion and other forms of cell death, this vibrant area of research widens its influ­ence and impor­tance for human health and disease.

    Top­ics and Speakers

    Wednes­day, Octo­ber 29, 2014

    • Keynote Address – Vishva M. Dixit, Genen­tech, Inc., USA
    • “Cell Death Sig­nal­ing I”Guy S. Salvesen, Sanford-​Burnham Med­ical Research Insti­tute, USA – Beth Levine, Uni­ver­sity of Texas South­west­ern Med­ical Cen­ter, USA – Mohan­ish Desh­mukh, Uni­ver­sity of North Car­olina at Chapel Hill, USA
    • Work­shop: “Can­cer“
    • “Cell Death Sig­nal­ing II”Dou­glas R. Green, St. Jude Children’s Research Hos­pi­tal, USA – Peter Van­den­abeele, VIB, Ghent Uni­ver­sity, Bel­gium – Fran­cis Ka-​Ming Chan, Uni­ver­sity of Mass­a­chu­setts Med­ical School, USA

    Thurs­day, Octo­ber 30, 2014

    • “Cell Death and Can­cer I”Andreas E. Strasser, Wal­ter and Eliza Hall Insti­tute of Med­ical Research, Aus­tralia – David W. Andrews, Uni­ver­sity of Toronto, Canada – Gerry Melino, Uni­ver­sity of Rome ‘Tor Ver­gata’, Italy – Rus­lan M. Medzhi­tov, HHMI/​Yale Uni­ver­sity School of Med­i­cine, USA
    • Work­shop: “Host Defense“
    • “Cell Death and Can­cer II”Ger­ard I. Evan, Uni­ver­sity of Cam­bridge, UK – Karen H. Vous­den, Beat­son Insti­tute for Can­cer Research, UK – Anthony G. Letai, Dana-​Farber Can­cer Insti­tute, USA

    Fri­day, Octo­ber 31, 2014

    • “Cell Death and Host Defense I”Petr Broz, Biozen­trum, Uni­ver­sity of Basel, Switzer­land – Thirumala-​Devi Kan­neganti, St. Jude Children’s Research Hos­pi­tal, USA – Karina R. Bor­toluci, Fed­eral Uni­ver­sity of São Paulo, Brazil
    • “Cell Death and Host Defense II”Akiko Iwasaki, Yale Uni­ver­sity School of Med­i­cine, USA – Gus­tavo P. Amarante-​Mendes, Uni­ver­si­dade de São Paulo, Brazil – Sea­mus J. Mar­tin, Trin­ity Col­lege Dublin, Ireland

    Sat­ur­day, Novem­ber 1, 2014

    • “Con­se­quences of Cell Death”Shigekazu Nagata, Kyoto Uni­ver­sity, Japan – Kim New­ton, Genen­tech, USA – Will Wood, Uni­ver­sity of Bris­tol, UK – Eric H. Baehrecke, Uni­ver­sity of Mass­a­chu­setts Med­ical School, USA
    • “Cell Death Ther­a­pies”David Ching Huang, Wal­ter and Eliza Hall Insti­tute of Med­ical Research, Australia
    starting: ending: 02.11.2014 Location: , Category:


    Conference START 02.11.2014 END

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