The European Association for Cancer Research (EACR) is kindly inviting you to participate in a Conference on Mechanisms and Relevance of Cell Death for Cancer Biology and Treatment entitled “A Matter of Life or Death“ which will be held on January 28 – 30, 2016 in Amsterdam, The Netherlands.
This EACR Conference is the third conference on this topic. Its objective is to cover recent and exciting developments in the field that are crucial to our understanding of the multifaceted role of cell death in tumour initiation, progression and therapy response.
Although our understanding of the mechanisms of apoptotic and non-apoptotic programmed cell death modes has increased enormously during the last decade, successful translation of our knowledge into clinical application to the benefit of patients is still challenging.
Research about the mechanisms of classical and non-classical modes of programmed cell death, and their dual role in tumour development and therapy response is a rapidly evolving field that has enormous impact on the development and implementation of novel treatment strategies.
Induction of cell death is the molecular basis of the cytotoxic action of many chemotherapeutic drugs and radiotherapy. Conversely, evading programmed cell death has been recognised as one major hallmark of cancer cells thereby contributing to therapy resistance. Cancer cells may even hijack tumour suppressor mechanisms like protective autophagy to survive adverse conditions in the tumour microenvironment. Otherwise, the mode of cell death is also an important determinant of the immune response resulting from therapy-induced tissue damage that may either increase the antitumor effect or be tumour promoting.
- The various modes of programmed cell death and their regulation, e.g. apoptosis, autophagy and necroptosis
- Cancer cell autonomous TRAIL-receptor signaling and cancer progression
- Ouroborous, autophagy and growth control
- The interplay of p53-mediated apoptosis and tumour suppression
- The protein interaction map of apoptosis and autophagy
- Autophaghy and cancer metabolism
- Importance and therapeutic exploitation of the cellular stress response, the ubiquitin proteasome system and cell death signalling for cancer therapy
- In vivo RNAi screening for the identification of new resistance mechanisms
- Precision cancer therapy targeting mitochondria
- New strategies to kill cancer stem cells
- Therapeutic targets in DNA repair
- Therapeutic reprograming of radiation-induced immune deviation in normal tissue responses.
This meeting is of interest to scientists from different fields of cancer research, such as cancer biology, molecular pathology, molecular oncology, cancer immunology, pharmacology, radiation biology and oncology, and medical oncology, as it will cover the multifaceted role of cell death in cancer ranging from basic mechanisms of cell death signalling and resistance, tumour microenvironment, tumour heterogeneity, and immune effects to target discovery and new therapy concepts.
Given its translational character, the conference is of broad interest for basic, translational and clinical researchers as well as for companies. We will provide ample opportunities for early stage basic and translational cancer researchers and young medical oncologists to present their work to the international community and to meet experts in the field in an inspiring informal atmosphere to share research findings and to establish or strengthen collaborations.
EACR Poster Prizes
Two EACR Poster Prizes of €100 each will be awarded for the best posters as selected by the judges. Certificates will be presented on Saturday 30 January during the summary and close of the meeting from 13.00 – 13.10.
Scientific Organising Committee
- Simone Fulda (Germany)
- Verena Jendrossek (Germany)
- Jan Paul Medema (the Netherlands)
EACR Meeting Bursaries
Application Deadline: 13 November 2015
Five bursaries will be awarded to assist members of the European Association for Cancer Research to attend the conference. The bursaries provide a full registration free of charge and funds of up to € 500 to support travel only. Participants must meet the cost of accommodation from their own funds.
In order to apply, you should:
- have been a member of the EACR for at least 3 months prior to the application
- have less than four years post-doctoral experience
- have difficulty in securing the necessary funding to participate in the conference
Applications should be accompanied by:
- One page CV
- One page list of your most relevant publications (if available)
- Signature of supervisor/team leader supporting the application
Completed application forms should be returned by the deadline via email to Roger Doxat-Pratt at the EACR Secretariat. Successful applicants will be notified as soon as possible after the application deadline.